Koselugo (Selumetinib) (Selumetinib) — Uses, Dosage, Side Effects & Safety

Drug class: MEK inhibitor (Mitogen-activated extracellular signal-regulated kinase inhibitor)

Overview

Koselugo (Selumetinib) is a prescription medication used to treat children aged 2 years and older with neurofibromatosis type 1 (NF1) who have symptomatic, inoperable plexiform neurofibromas. NF1 is a genetic disorder that causes tumors to grow along nerves in the skin, brain, and other parts of the body. Koselugo works by blocking specific proteins (MEK1 and MEK2) involved in cell signaling pathways that promote tumor growth. By inhibiting these proteins, Selumetinib helps slow or shrink the growth of certain tumors. Key points for patients: Koselugo is taken by mouth as capsules, usually twice daily. It is important to take the medication exactly as prescribed and to attend all scheduled follow-up appointments for monitoring. Koselugo can cause side effects, some of which may be serious, so regular check-ups and communication with your healthcare provider are essential.

Therapeutic uses

  • Neurofibromatosis type 1 (NF1) with symptomatic, inoperable plexiform neurofibromas (PNs)
  • Pediatric low-grade glioma (off-label)
  • Thyroid cancer (off-label)

Common side effects

  • Diarrhea
  • Vomiting
  • Nausea
  • Skin rash
  • Fatigue
  • Muscle pain
  • Swelling
  • Changes in vision

Frequently Asked Questions about Koselugo (Selumetinib)

What conditions does Koselugo (Selumetinib) treat?

Koselugo is approved to treat children aged 2 years and older with neurofibromatosis type 1 (NF1) who have symptomatic, inoperable plexiform neurofibromas.

How should I take Koselugo?

Take Koselugo capsules by mouth, twice daily, on an empty stomach (at least 1 hour before or 2 hours after food). Swallow the capsules whole with water.

What are the most common side effects?

Common side effects include diarrhea, nausea, vomiting, abdominal pain, fatigue, rash, dry skin, and swelling around the eyes.

Can Koselugo be used during pregnancy?

Koselugo can cause harm to an unborn baby. It should not be used during pregnancy, and effective contraception is recommended during treatment and for at least 1 week after the last dose.

What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is less than 6 hours until your next dose. Do not double up doses.

Are there any foods or drugs I should avoid while taking Koselugo?

Avoid grapefruit and grapefruit juice, and do not take Koselugo with food. Inform your doctor about all other medications, especially those affecting CYP3A4 enzymes.

How will my doctor monitor me while on Koselugo?

Your doctor will monitor your heart function, liver enzymes, eye health, and for signs of bleeding or other side effects through regular check-ups and laboratory tests.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.