Kineret (Anakinra) (anakinra) — Uses, Dosage, Side Effects & Safety

Drug class: Interleukin-1 (IL-1) receptor antagonist; Immunomodulator

Overview

Kineret (anakinra) is a prescription medication used to treat moderate to severe rheumatoid arthritis in adults who have not responded well to other treatments. It is also approved for the treatment of Cryopyrin-Associated Periodic Syndromes (CAPS), including Neonatal-Onset Multisystem Inflammatory Disease (NOMID), and for Still’s disease, including systemic juvenile idiopathic arthritis (SJIA) and adult-onset Still’s disease (AOSD). Kineret works by blocking the activity of interleukin-1 (IL-1), a protein in the body that can cause inflammation and joint damage. By inhibiting IL-1, Kineret helps reduce pain, swelling, and other symptoms of inflammatory diseases. Key points for patients: Kineret is given as a daily injection under the skin. It may increase your risk of infections, so regular monitoring is important. Always follow your healthcare provider’s instructions and report any signs of infection or unusual symptoms.

Therapeutic uses

  • Rheumatoid arthritis (RA)
  • Cryopyrin-associated periodic syndromes (CAPS)
  • Still's disease (systemic juvenile idiopathic arthritis and adult-onset Still's disease)
  • Deficiency of the interleukin-1 receptor antagonist (DIRA)

For related Kineret (Anakinra) guidance, compare Rheumatoid Arthritis (RA): A Comprehensive Guide to Symptoms, Causes, and Treatment.

Common side effects

  • Injection site reactions
  • Headache
  • Nausea
  • Diarrhea
  • Neutropenia
  • Serious infections
  • Hypersensitivity reactions

Frequently Asked Questions about Kineret (Anakinra)

What conditions does Kineret treat?

Kineret is used to treat moderate to severe rheumatoid arthritis, Cryopyrin-Associated Periodic Syndromes (CAPS), and Still’s disease (systemic juvenile idiopathic arthritis and adult-onset Still’s disease).

How is Kineret administered?

Kineret is given as a subcutaneous injection (under the skin), usually once daily. Patients or caregivers may be trained to administer the injections at home.

What are the most common side effects?

The most common side effects are injection site reactions (redness, swelling, pain), headache, and upper respiratory tract infections.

Can I receive vaccines while on Kineret?

You should avoid live vaccines while taking Kineret, as your immune response may be weakened. Inactivated vaccines are generally considered safe but discuss with your doctor first.

What should I do if I develop a fever or signs of infection?

Contact your healthcare provider immediately if you develop a fever, chills, or other signs of infection. Kineret can increase your risk of serious infections.

Is Kineret safe during pregnancy or breastfeeding?

There is limited data on the use of Kineret in pregnancy and breastfeeding. Discuss the risks and benefits with your healthcare provider before starting treatment.

How should I store Kineret?

Store Kineret in the refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light and keep out of reach of children.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.