Jardiamet / Jardiance Duo / Jardiance Plus (Empagliflozin and Metformin hydrochloride) — Uses, Dosage, Side Effects & Safety

Drug class: Antidiabetic agent (SGLT2 inhibitor and Biguanide combination)

Overview

Jardiamet, Jardiance Duo, and Jardiance Plus are combination medicines used to help control blood sugar levels in adults with type 2 diabetes mellitus. They contain two active ingredients: empagliflozin (an SGLT2 inhibitor) and metformin (a biguanide). These medications are prescribed when diet, exercise, and single-agent therapy do not provide adequate blood sugar control. Empagliflozin works by helping your kidneys remove excess sugar from your body through urine, while metformin reduces the amount of sugar produced by your liver and improves your body's response to insulin. Together, they help lower blood glucose and may also reduce the risk of heart and kidney complications in people with type 2 diabetes. Key points: These medicines are not for type 1 diabetes or diabetic ketoacidosis. They are usually taken once or twice daily with meals to reduce stomach upset. Regular monitoring of blood sugar and kidney function is important during treatment.

Therapeutic uses

  • Type 2 diabetes mellitus
  • Reduction of risk of cardiovascular death in adults with type 2 diabetes mellitus and established cardiovascular disease
  • Reduction of the risk of cardiovascular death and hospitalization for heart failure in adults with heart failure (NYHA class II-IV) with reduced ejection fraction

For related Jardiamet / Jardiance Duo / Jardiance Plus guidance, compare Metformin in Canada, Metformin in France and Metformin in United States.

Common side effects

  • Hypoglycemia
  • Urinary tract infections
  • Genital yeast infections
  • Diarrhea
  • Nausea
  • Ketoacidosis
  • Lactic acidosis
  • Dehydration

Frequently Asked Questions about Jardiamet / Jardiance Duo / Jardiance Plus

What is Jardiamet / Jardiance Duo / Jardiance Plus used for?

These medicines are used to help control blood sugar in adults with type 2 diabetes, especially when single-agent therapy is not enough. They may also help reduce the risk of heart and kidney complications.

How does this medication work?

It combines empagliflozin, which helps the kidneys remove excess sugar, and metformin, which reduces sugar production in the liver and improves insulin sensitivity.

Can I take this medicine if I have kidney problems?

It is not recommended for people with severe kidney impairment. Your doctor will check your kidney function before and during treatment.

What should I do if I experience side effects?

Mild side effects may improve over time. If you experience severe symptoms such as difficulty breathing, severe stomach pain, or signs of lactic acidosis, seek medical help immediately.

Can I use this medication during pregnancy or breastfeeding?

It is not recommended during pregnancy or breastfeeding unless clearly needed and prescribed by your doctor. Discuss risks and benefits with your healthcare provider.

What foods or drinks should I avoid?

Avoid excessive alcohol, which increases the risk of lactic acidosis. Stay hydrated and follow your healthcare provider's dietary advice.

How often should my blood sugar and kidney function be monitored?

Your doctor will recommend regular blood sugar checks and periodic kidney function tests, especially at the start of therapy and during dose adjustments.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.