Isavuconazole — Uses, Dosage, Side Effects & Safety

Drug class: Antifungal (Triazole antifungal agent)

Overview

Isavuconazole is a prescription antifungal medication used to treat serious fungal infections, including invasive aspergillosis and invasive mucormycosis. These infections typically affect people with weakened immune systems, such as those undergoing chemotherapy, organ transplantation, or with certain blood disorders. Isavuconazole works by stopping the growth of fungi. It does this by interfering with the production of ergosterol, an essential component of fungal cell membranes. Without ergosterol, the fungal cells become unstable and die. Key points for patients: Isavuconazole is usually started in a hospital setting and may be continued at home. It is important to take the medication exactly as prescribed and to complete the full course, even if you start to feel better. Let your healthcare provider know about all other medicines you are taking, as isavuconazole can interact with many drugs.

Therapeutic uses

  • Invasive aspergillosis
  • Invasive mucormycosis

For related Isavuconazole guidance, compare Fluconazole, Voriconazole and Itraconazole.

Common side effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Headache
  • Elevated liver enzymes
  • Hypokalemia
  • QTc interval shortening

Frequently Asked Questions about Isavuconazole

What infections does isavuconazole treat?

Isavuconazole is used to treat invasive aspergillosis and invasive mucormycosis, which are serious fungal infections often seen in immunocompromised patients.

How long do I need to take isavuconazole?

The duration depends on the type and severity of infection and your response to treatment. Your doctor will determine the appropriate length of therapy, which may range from several weeks to months.

Can I take isavuconazole with food?

Yes, isavuconazole capsules can be taken with or without food. Swallow the capsules whole.

What should I do if I experience side effects?

Contact your healthcare provider if you experience mild side effects. Seek immediate medical attention for severe reactions such as jaundice, severe rash, or difficulty breathing.

Is isavuconazole safe during pregnancy?

Isavuconazole should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Discuss with your doctor if you are pregnant or planning to become pregnant.

Are there any foods or drugs I should avoid while taking isavuconazole?

Avoid grapefruit products and strong CYP3A4 inducers such as rifampin and St. John's wort. Always review your medication list with your healthcare provider.

How is isavuconazole different from other antifungals?

Isavuconazole has a broad spectrum of activity and is effective against both Aspergillus and Mucorales species. It also has a lower risk of causing QT prolongation compared to other azoles, but may shorten the QT interval.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.