Glipizide + Metformin (Glipizide and Metformin Hydrochloride) — Uses, Dosage, Side Effects & Safety

Drug class: Oral Antidiabetic Combination (Sulfonylurea + Biguanide)

Overview

Glipizide + Metformin is a combination oral medication used to help control blood sugar levels in adults with type 2 diabetes mellitus. It is prescribed when diet and exercise alone are not enough to manage blood glucose effectively. This medicine combines two different diabetes medicines: glipizide, which helps your pancreas release more insulin, and metformin, which helps your body use insulin better and reduces the amount of sugar made by your liver. Key points for patients: Take this medication exactly as prescribed, usually with meals to reduce stomach upset. Regular blood sugar monitoring is important. This medicine is not for use in type 1 diabetes or diabetic ketoacidosis.

Therapeutic uses

  • Type 2 Diabetes Mellitus
  • Glycemic control in adults with type 2 diabetes
  • Adjunct to diet and exercise for type 2 diabetes

For related Glipizide + Metformin guidance, compare Metformin in Canada, Metformin in France and Metformin in United States.

Common side effects

  • Hypoglycemia
  • Diarrhea
  • Nausea
  • Abdominal pain
  • Lactic acidosis
  • Headache
  • Dizziness

Frequently Asked Questions about Glipizide + Metformin

What is Glipizide + Metformin used for?

It is used to help control blood sugar in adults with type 2 diabetes when diet and exercise alone are not enough.

How should I take Glipizide + Metformin?

Take the medication exactly as prescribed, usually with meals to reduce stomach upset. Do not crush or chew extended-release tablets.

What should I do if I miss a dose?

Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not double up doses.

What are the serious side effects I should watch for?

Watch for signs of lactic acidosis (rapid breathing, muscle pain, severe drowsiness), severe hypoglycemia, allergic reactions, or liver problems. Seek immediate medical attention if these occur.

Can I drink alcohol while taking this medication?

Limit or avoid alcohol as it increases the risk of lactic acidosis and hypoglycemia.

Is Glipizide + Metformin safe during pregnancy or breastfeeding?

Safety in pregnancy and breastfeeding is not well established. Discuss with your healthcare provider before use.

Can children take Glipizide + Metformin?

This medication is not routinely recommended for children under 18 years, as safety and efficacy have not been established.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.