Fluorescein — Uses, Dosage, Side Effects & Safety

Drug class: Diagnostics, Procedures & Systems

Overview

Fluorescein is a diagnostic dye used primarily in eye care to help doctors detect damage or disease in the cornea, diagnose dry eye, and visualize blood vessels in the retina during angiography. It is also used intravenously to highlight blood vessels in the back of the eye for detailed imaging. When applied to the eye, fluorescein temporarily stains the tear film and any damaged areas of the cornea, making them visible under a blue light. When injected into a vein, it circulates through the blood vessels in the eye, allowing doctors to take photographs and assess blood flow or identify blockages. Key points: Fluorescein is not a treatment but a diagnostic tool. The dye is usually well tolerated, but some people may experience mild irritation or, rarely, allergic reactions. The yellow-orange color may temporarily stain skin or urine.

Therapeutic uses

• Ophthalmic angiography
• Retinal angiography
• Angiography of the iris vasculature
• Detection of corneal injury
• Evaluation of tear film integrity

For related Fluorescein guidance, compare Histamine phosphate injection, Iodixanol (contrast agent) and Ioversol (contrast agent).

Common side effects

• Nausea
• Vomiting
• Dizziness
• Headache
• Hives
• Anaphylaxis
• Seizures

Frequently Asked Questions about Fluorescein

What is fluorescein used for?

Fluorescein is used to help doctors diagnose eye conditions, such as corneal abrasions, dry eye, and retinal blood vessel disorders. It is also used in angiography to visualize blood flow in the eye.

Is fluorescein safe?

Fluorescein is generally safe when used as directed by a healthcare professional. Mild side effects are common, but serious reactions are rare.

How long does fluorescein stay in the body?

Fluorescein is rapidly eliminated from the body, usually within 24 to 36 hours. Temporary yellow discoloration of urine may occur.

Can I drive after a fluorescein eye test?

You may experience blurred vision for a short time after the test. Wait until your vision clears before driving or operating machinery.

Can fluorescein be used during pregnancy?

Fluorescein should only be used during pregnancy if clearly needed and prescribed by your doctor. Discuss risks and benefits with your healthcare provider.

Will fluorescein stain my skin or clothes?

Fluorescein may temporarily stain skin or clothing yellow-orange, but this usually fades quickly.

What should I do if I have an allergic reaction to fluorescein?

Seek immediate medical attention if you experience symptoms such as difficulty breathing, swelling, or severe rash after fluorescein administration.

Educational information only. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.