Delafloxacin

Pronunciation: Not available from supplied research notes..

Generic name: delafloxacin
Brand names: BAXDELA
Drug class: Fluoroquinolone antibiotic
Form: Tablets (450 mg) and intravenous vial (300 mg before reconstitution)
Route: Oral and intravenous
Legal status: Prescription-only medicine

Availability and supply rules vary by country

Trade names by country: United States

What delafloxacin is and how it works

Delafloxacin is an oral and intravenous fluoroquinolone antibiotic for the treatment of acute bacterial skin and skin-structure infections (ABSSSI) and community-acquired bacterial pneumonia (CABP) in adults, caused by susceptible bacteria as per current U.S. labelling. (1)

Only U.S. labelling verified; availability in other countries is unresolved. A prescriber must confirm susceptible organisms, indication, and individual risk-benefit prior to use.

Mechanism of action: how delafloxacin works

Delafloxacin is a fluoroquinolone antibacterial agent. (1)

What delafloxacin is used for

Acute bacterial skin and skin-structure infections

For treatment of adults with ABSSSI caused by susceptible bacteria, as per the current U.S. prescribing information. (1)

Community-acquired bacterial pneumonia

For treatment of adults with CABP caused by susceptible bacteria, as per the current U.S. prescribing information. (1)

Before taking delafloxacin

Do not take / not appropriate for

Do not take delafloxacin if you have a known hypersensitivity to delafloxacin or any other fluoroquinolone antibiotic. (all products) (1)
Do not take delafloxacin if you have myasthenia gravis, as it may exacerbate muscle weakness. (all products) (1)

Tell your clinician about

History of tendon problems (especially with previous fluoroquinolone use), nerve damage (peripheral neuropathy), or seizures.
Myasthenia gravis, kidney disease, diabetes, or risk factors for blood glucose disturbances.
Known aortic aneurysm or dissection, or family history of these conditions.
Pregnancy, plans for pregnancy, or breastfeeding.
All other medications, especially oral antacids, sucralfate, metal cations (e.g., iron, zinc), or buffered drugs.

(1)

How to take delafloxacin

Take delafloxacin exactly as prescribed by your healthcare provider, for the full duration of treatment.
Oral tablets may be taken with or without food; however, avoid taking within 2 hours of antacids, sucralfate, dairy products, or supplements containing aluminium, magnesium, calcium, iron, or zinc.
Intravenous delafloxacin is administered by a healthcare professional in a clinical setting.
Do not change the dose, route, or duration of treatment yourself.

(1)

Procedures and treatment changes

Tell the treating team before surgery, procedures, or any medicine change. Do not alter treatment without the responsible clinician. (1)

Missed dose

If a dose is missed, contact the prescribing provider for instructions. do not take an extra dose to make up for a missed one.

Overdose

If overdose is suspected, seek emergency medical attention immediately. Symptoms may include central nervous system effects or seizures. (1)

Side effects

The side effect profile for delafloxacin is not fully detailed in the supplied research notes. The following serious warnings are based on the available U.S. label; common side effects are not enumerated in the provided material.

Insufficient data in supplied notes

What to notice: Refer to the full prescribing information for a complete list of common adverse reactions.

What to do: Report any troublesome or persistent symptoms to your prescriber. (1)

Tendon pain or swelling

What to notice: Pain, swelling, or inflammation of a tendon (e.g., Achilles, shoulder, hand).

What to do: Seek prompt medical evaluation, and let the clinician advise on continuing or stopping therapy. (1)

Nerve symptoms (peripheral neuropathy)

What to notice: Pain, burning, tingling, numbness, or weakness, especially in the hands or feet.

What to do: Report symptoms immediately to your healthcare provider. (1)

Central nervous system effects

What to notice: Dizziness, confusion, tremors, hallucinations, or seizures.

What to do: Seek medical attention promptly if these occur. (1)

Hypersensitivity reactions

What to notice: Rash, hives, difficulty breathing, swelling of the face or throat.

What to do: Seek emergency medical help immediately and let the treating clinician advise on whether to continue delafloxacin. (1)

C. difficile-associated diarrhea

What to notice: Persistent or severe diarrhea, possibly with blood or mucus, abdominal pain.

What to do: Contact your prescriber promptly; do not use anti-diarrhea medicines without advice. (1)

Blood glucose disturbances

What to notice: Symptoms of high blood sugar (increased thirst/urination) or low blood sugar (sweating, shaking, confusion).

What to do: Monitor blood glucose if diabetic and report significant changes to your provider. (1)

Aortic aneurysm or dissection

What to notice: Sudden severe chest, back, or abdominal pain.

What to do: Seek emergency medical care immediately. (1)

Serious warnings

Anaphylaxis/Hypersensitivity — emergency

Symptoms: Difficulty breathing, throat tightness, swelling of the face/tongue, rapid heartbeat, hives, or fainting.

Action: Seek emergency medical care immediately and let the treating clinician advise on whether to continue delafloxacin. (1)

Tendon rupture or tendinitis — seek_medical_attention_promptly

Symptoms: Sudden pain, swelling, or snapping sensation in a tendon area; difficulty moving a joint.

Action: seek medical advice promptly, and let the clinician you see advise on whether to continue or stop delafloxacin; rest the affected limb and avoid exercise until evaluated. (1)

Peripheral neuropathy — seek_medical_attention_promptly

Symptoms: Pain, burning, tingling, numbness, or weakness in the extremities.

Action: Report these symptoms to your healthcare provider without delay and let them decide whether treatment should continue. (1)

Central nervous system effects — seek_medical_attention_promptly

Symptoms: Seizures, confusion, hallucinations, depression, or severe dizziness.

Action: Seek urgent medical advice if these occur and let the clinician decide whether delafloxacin should continue. (1)

Exacerbation of myasthenia gravis — seek_medical_attention_promptly

Symptoms: Worsening muscle weakness, especially respiratory muscles, difficulty swallowing, or drooping eyelids.

Action: Seek emergency care if breathing becomes difficult; inform all healthcare providers of myasthenia gravis diagnosis before treatment. (1)

Interactions

Medicine or test	Effect	Action
Multivalent cation-containing products (antacids, sucralfate, dairy, supplements with Ca, Mg, Al, Fe, Zn)	Oral absorption of delafloxacin is significantly reduced, potentially leading to treatment failure.	Take oral delafloxacin at least 2 hours before or after any product containing these cations. Discuss all supplements and OTC medications with your prescriber or pharmacist. (1)

Pregnancy, breastfeeding, kidney/liver function, age

Renal impairment

Delafloxacin requires dose adjustment in patients with reduced kidney function. Your prescriber will determine the appropriate dose and route based on renal function. (1)

Pregnancy and breastfeeding

There are no adequate studies in pregnant women. Discuss potential risks and benefits, including continuation decisions, with your prescriber. (1)

Children

Safety and efficacy have not been established in paediatric patients. Delafloxacin is not approved for use in children based on current U.S. labelling. (1)

Monitoring

Before starting

Detailed monitoring parameters are not provided in the supplied research notes. Refer to full prescribing information for recommended assessments prior to therapy.

During treatment

Monitoring requirements during treatment are not specified in the supplied notes; consult the local product label for guidance.

(1)

Storage

Storage instructions are not detailed in the supplied research notes. Refer to the product packaging or labelling for specific conditions.

Professional information

This single-source, U.S.-centric draft is for clinician-facing context only. Dosing, renal adjustment, contraindications, and safety data may vary; always consult the complete current prescribing information.

United States (sole verified label)

Indication: ABSSSI or CABP

Dose summary: Detailed dosing regimens are not included in the supplied notes. Refer to the current U.S. Baxdela label for weight- and renal-function-based dosing.

Renal context: Dose adjustment is required in renal impairment; specifics are not provided in the research notes. Use the full prescribing information. (1)

Mechanism of action

Hepatic guidance

No hepatic impairment information is available in the supplied research notes.

Overdose note

Overdose management is not detailed in the supplied notes; consult a poison control centre and provide supportive care. (1)

Frequently asked questions

Can I take antacids or dairy products with delafloxacin?

Antacids, supplements, and dairy products containing aluminium, magnesium, calcium, iron, or zinc can reduce the absorption of oral delafloxacin. It is recommended to take delafloxacin at least 2 hours before or after such products. Discuss your full medication and supplement list with your prescriber or pharmacist. (1)

What should I do if I experience tendon pain while taking delafloxacin?

Tendon pain, swelling, or inflammation can be a sign of tendon damage. Contact your prescribing clinician promptly and let them advise on whether to continue the course or switch therapy. (1)

Is delafloxacin safe during pregnancy?

There is limited information on delafloxacin in pregnancy. Tell your prescriber if you are pregnant or planning pregnancy so they can discuss risks, benefits, and continuation decisions. (1)

What is the mechanism of action of delafloxacin?